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Protein intake for cognitive function

Protein intake for cognitive function

Cognitive functions were assessed Funnction a series of cognitive tests. FAO Food and Nutrition Paper No. Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia. Protein intake for cognitive function

Protein intake for cognitive function -

We observed a consistent upregulation of cytokines CXCL10 , CCL3 following immune challenge across cell types, including microglia. Such in vitro patterns of expression following an immune challenge indicate the positive associations of inflammatory diet with candidate proteins in the current study may reflect pro-inflammatory responses CXCL10, CCL3 or compensatory, anti-inflammatory patterns of regulation NFATC3, HGF, CDCP1 that alter risk for subsequent cognitive impairment.

To further understand candidate protein biology and determine their potential role in AD, we utilized several complementary, publicly available resources. Using STRING protein-protein interaction network analyses and functional enrichment, we found that three of our candidate proteins CXCL10, CCL3, HGF involved in cellular locomotion in response to chemical stimulus i.

Leveraging data obtained from comprehensive post-mortem brain tissue collections, along with expression data via the AMP-AD Sage Bionetworks Agora platform, we also observed five of our candidate proteins OPG, HGF, NFATC3, CDCP1, ITGA11 display upregulated expression in the brains of AD individuals and maintain expression quantitative trait loci eQTL in brain tissue.

These results suggest that at least five of the seven inflammatory diet proteins identified in plasma and linked to cognitive impairment may be differentially expressed in the brains of individuals at risk for AD and regulated, at least in part, by underlying genetic variation Fig.

While one of the proteins linked to EDII and incident cognitive impairment CXCL10 has been nominated as a therapeutic target for AD, three candidate proteins CCL2, CXCL10, and HGF are therapeutic targets of ongoing clinical trials for non-neurologic disease Supplementary Table The current findings provide insights into how inflammatory nutritional patterns relate to an immune-related plasma proteome.

Together, these results highlight the molecular mediators through which an inflammatory diet may contribute to the risk for age-related cognitive impairment and dementia. While previous investigations have demonstrated a relationship between inflammatory diet and a select group of inflammatory proteins e.

Several lines of evidence indicate that the patterns of protein expression reported here indeed reflect diets with differing inflammatory potential. First, we observed significant correlations of EDII scores with increasing levels of IL-6 and TNF, two pro-inflammatory cytokines previously used to validate anti-inflammatory diets e.

In addition, many of the proteins significantly correlated with energy-adjusted diet scores in our study FGF, IL-6, ILR1, FGF, CSF-1, HGF, CCL20, ILB, VEGFA, ILRB, IL, TRANCE, CCL3, CDCP1, TWEAK were also related to BMI in a recently published RCT, where changes in these proteins also tracked changes in BMI following a healthy dietary intervention [ 33 ].

The upregulation of nine immunologically relevant pathways in the context of higher EDII scores further supports the concept of a broad, diet-induced immune stimulation, and calls attention to specific cellular processes extracellular matrix organization, inflammatory response, response to cytokine stimulus by which pro-inflammatory diets may contribute to disrupted cellular homeostasis.

Notably, the apoptotic process composite score, which was positively associated with baseline EDII scores as well as incident cognitive impairment in this study, was also found in the Swedish BioFINDER study to distinguish amyloid-positive AD and amyloid-positive MCI participants from amyloid-negative cognitively normal and MCI individuals [ 35 ].

Adding to these previous findings, our results suggest that the regulation of proteins in this cell-death signaling cascade may be augmented by an inflammatory diet and relate—perhaps mechanistically—to amyloid deposition, at least during the initial stages of cognitive decline. The candidate proteins we identified have been associated with cognitive decline in other studies using similar proteomic assays, providing further support to our findings.

Higher plasma levels of CDCP1, OPG, and HGF have been shown to accurately discriminate dementia cases from cognitively normal older adults [ 58 , 59 , 60 ]. Furthermore, differing concentrations of plasma ITGA11 and NFATC3, and elevated intrathecal CCL3 have been observed among individuals diagnosed with AD, while abnormal levels of CXCL10 in CSF or plasma are found across multiple neurodegenerative phenotypes, including FTD and AD [ 59 , 61 , 62 , 63 ].

Of note, we observed consistency in directionality of the relationship between protein level and cognitive impairment, i. The consistency of these results reinforces prior studies that report increased dementia incidence tied to pro-inflammatory diets [ 11 , 12 , 13 , 14 , 15 ] and extends these findings by revealing specific plasma proteins that may link an inflammatory diet to cognitive dysfunction in aging.

Our assessment of inflammatory diet proteins in relation to plasma biomarkers of AD pathology and neurodegeneration adds to the limited understanding of how dietary patterns may influence pathological processes within the CNS [ 64 , 65 , 66 ]. Of the seven plasma proteins linked to pro-inflammatory diet and cognitive impairment, four and three were positively associated with NfL and an MRI measure of AD-relevant brain atrophy, respectively.

These findings support the well-documented relationship between peripheral inflammation and neurodegeneration [ 67 , 68 , 69 , 70 ]. These results are consistent with recent data suggesting immune activation may limit deposition of brain Aβ among individuals at-risk for cognitive deficits [ 71 , 72 , 73 ].

While it is unlikely that an inflammatory diet has a protective effect on Aβ pathology, individuals predisposed to mount a more robust immune response to an inflammatory diet may also mount a stronger response to brain Aβ deposition, at least initially.

While the observational nature of this study precludes any determination of causality, our results nonetheless suggest that proteins linked to an inflammatory diet may contribute to neuronal injury.

We note, however, that although we show CCL3 and OPG are positively associated with neurodegeneration biomarkers in two separate cohorts, other investigations have failed to find associations between plasma CCL3, OPG, and atrophy in brain regions commonly implicated in AD [ 74 , 75 ].

These three proteins may be especially responsive to immunologic stressors, and in the context of our results, may play a role in regulating the effects of pro-inflammatory processes on target cells within the brain. While all five proteins have been previously implicated in AD, our results suggest that an inflammatory diet may be a key driver of these AD-associated proteins [ 58 , 59 , 60 , 61 , 62 , 63 ].

Interestingly, three of the seven candidate proteins are cytokines with known patterns of co-expression. One of these proteins, CXCL10 also known as interferon gamma-induced protein 10 , acts as a ligand for CXCR3, thereby promoting activation of monocytes and natural killer cells, as well as the migration of T-cells [ 76 ].

Accordingly, CXCL10 has been nominated by the Accelerated Medicine Partnership as a potential therapeutic target for AD.

First, because of the goals of the parent study WHIMS ancillary study , participants were limited to white women. Although protein-dementia associations replicated in more diverse external samples, additional studies will be needed to determine the generalizability of results to other demographic groups.

Second, the use of a matched case-control design for the WHIMS ancillary study precluded the use of time-to-event analyses, which may be better suited to detect protein-cognitive impairment associations. Third, while an inflammatory diet was previously associated with risk for incident cognitive impairment in a group of participants from the parent WHIMS study [ 14 ], the current analysis was restricted to a more deeply phenotyped subset of participants at approximately one-fifth the size.

In turn, limited power to detect the DII-cognitive impairment association demonstrated previously precluded the use of formal mediation models. Fourth, given the observational nature of this study, the extent to which diet and proteins exert causal effects, as well as the directionality of these effects, are unknown.

We encourage future preclinical investigations to establish temporal precedence and the associated causality between components of pro-inflammatory diets e. Fifth, the associations between inflammatory protein levels and inflammatory diet scores were weak, consistent with prior reports [ 29 , 78 , 79 , 80 ].

or that measurement error inherent in the retrospective self-reported dietary assessment [ 81 ] attenuated true associations between inflammatory diet scores and inflammatory protein levels. Additionally, biological fluctuations e. Therefore, null effects should be interpreted with appropriate caution.

However, numerous studies have demonstrated that outside the context of an acute infection or injury, levels for many inflammatory proteins—and plasma proteins more broadly—remain relatively stable across time [ 83 , 84 ]. Despite these limitations, the current results provide insights into the molecular conduits through which pro-inflammatory nutritional habits may contribute to cognitive impairment.

Follow-up studies will be needed to determine whether the identified proteins indeed play a causal, mechanistic role in late-life cognitive decline and dementia.

Duggan MR, Parikh V. Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging. Behav Brain Res. Article PubMed PubMed Central Google Scholar. Franceschi C, Campisi J.

Chronic Inflammation Inflammaging and Its Potential Contribution to Age-Associated Diseases. J Gerontology. Google Scholar. Gu Y, Manly JJ, Mayeux RP, Brickman AM. An Inflammation-related Nutrient Pattern is Associated with Both Brain and Cognitive Measures in a Multiethnic Elderly Population.

Curr Alzheimer Res. Article CAS PubMed PubMed Central Google Scholar. McGrattan AM, McGuinness B, McKinley MC, Kee F, Passmore P, Woodside JV, et al. Curr Nutr Rep. Corley J, Shivappa N, Hébert JR, Starr JM, Deary IJ. Associations between Dietary Inflammatory Index Scores and Inflammatory Biomarkers among Older Adults in the Lothian Birth Cohort Study.

J Nutr Health Aging. Shivappa N, Steck SE, Hurley TG, Hussey JR, Ma Y, Ockene IS, et al. A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study SEASONS.

Public Health Nutr. Article PubMed Google Scholar. Shivappa N, Hebert JR, Marcos A, Diaz LE, Gomez S, Nova E, et al. Association between dietary inflammatory index and inflammatory markers in the HELENA study. Mol Nutr Food Res. Shivappa N, Hébert JR, Rietzschel ER, De Buyzere ML, Langlois M, Debruyne E, et al.

Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study. Br J Nutr. Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR.

Designing and developing a literature-derived, population-based dietary inflammatory index. Tabung FK, Steck SE, Zhang J, Ma Y, Liese AD, Agalliu I, et al. Construct validation of the dietary inflammatory index among postmenopausal women.

Ann Epidemiol. Frith E, Shivappa N, Mann JR, Hébert JR, Wirth MD, Loprinzi PD. Dietary inflammatory index and memory function: population-based national sample of elderly Americans. Kesse-Guyot E, Assmann KE, Andreeva VA, Touvier M, Neufcourt L, Shivappa N, et al. Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.

MAX study. Eur J Nutr. Article CAS PubMed Google Scholar. Shin D, Kwon SC, Kim MH, Lee KW, Choi SY, Shivappa N, et al. Inflammatory potential of diet is associated with cognitive function in an older adult Korean population.

Hayden KM, Beavers DP, Steck SE, Hebert JR, Tabung FK, Shivappa N, et al. Alzheimers Dement. Charisis S, Ntanasi E, Yannakoulia M, Anastasiou CA, Kosmidis MH, Dardiotis E, et al. Diet Inflammatory Index and Dementia Incidence.

Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, et al. Rapp SR, Espeland MA, Shumaker SA, Henderson VW, Brunner RL, Manson JE, et al. Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS, et al. Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, et al. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al.

Control Clin Trials. Article Google Scholar. Shumaker SA, Reboussin BA, Espeland MA, Rapp SR, McBee WL, Dailey M, et al. Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T. Anderson GL, Manson J, Wallace R, Lund B, Hall D, Davis S, et al.

Block G, Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. Block G, Hartman AM, Naughton D.

A reduced dietary questionnaire: development and validation. Zabetian-Targhi F, Srikanth VK, Smith KJ, Oddy PhDW, Beare R, Moran C, et al.

Associations Between the Dietary Inflammatory Index, Brain Volume, Small Vessel Disease, and Global Cognitive Function. J Acad Nutr Diet.

Ferreira M, Cronjé HT, van Zyl T, Bondonno NP, Pieters M. The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans. Public Health Nutr ;— Kotemori A, Sawada N, Iwasaki M, Yamaji T, Shivappa N, Hebert JR, et al.

Dietary Inflammatory Index Is Associated With Inflammation in Japanese Men. Front Nutr. Rafiee P, Shivappa N, Hébert JR, Jaafari Nasab S, Bahrami A, Hekmatdoost A, et al. Dietary Inflammatory Index and Odds of Colorectal Cancer and Colorectal Adenomatous Polyps in a Case-Control Study from Iran.

Assarsson E, Lundberg M, Holmquist G, Björkesten J, Thorsen SB, Ekman D, et al. Homogenous plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability.

PLoS One. Lundberg M, Eriksson A, Tran B, Assarsson E, Fredriksson S. Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood.

Nucleic Acids Res. Figarska SM, Rigdon J, Ganna A, Elmståhl S, Lind L, Gardner CD, et al. Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention.

Sci Rep. Trares K, Bhardwaj M, Perna L, Stocker H, Petrera A, Hauck SM, et al. Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study.

Alzheimers Res Ther. Cullen NC, Mälarstig AN, Stomrud E, Hansson O, Mattsson-Carlgren N. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment an evidence-based review. Report of the Quality Standards Subcommittee of the American Academy of Neurology.

American Psychiatric Publishing. Diagnostic and statistical manual of mental disorders, 4th ed. Arlington, VA, US: American Psychiatric Publishing, Inc. xxvii, xxvii, p. Walker KA, Chen J, Zhang J, Fornage M, Yang Y, Zhou L, et al.

Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk. Nat Aging. Shock NW, Greulich RC, Aremberg D, Costa PT, Lakatta EG, Tobin JD. Normal human aging: The Baltimore longitudinal study of aging.

Washington, D. Armstrong NM, An Y, Doshi J, Erus G, Ferrucci L, Davatzikos C, et al. Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss.

JAMA Otolaryngol Head Neck Surg. Armstrong NM, An Y, Shin JJ, Williams OA, Doshi J, Erus G, et al. Associations between cognitive and brain volume changes in cognitively normal older adults. Varadaraj V, Munoz B, Deal JA, An Y, Albert MS, Resnick SM, et al. Association of Vision Impairment With Cognitive Decline Across Multiple Domains in Older Adults.

JAMA Netw Open. Davatzikos C, Xu F, An Y, Fan Y, Resnick SM. Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ. Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification.

Neurobiol Aging. Fan Y, Shen D, Gur RC, Gur RE, Davatzikos C. COMPARE: classification of morphological patterns using adaptive regional elements. IEEE Trans Med imaging. Cortes C, Vapnik V. Support-vector networks. Mach Learn. Da X, Toledo JB, Zee J, Wolk DA, Xie SX, Ou Y, et al. Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers.

NeuroImage: Clin. Toledo JB, Weiner MW, Wolk DA, Da X, Chen K, Arnold SE, et al. Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition. Acta neuropathol Commun. Vapnik V. The nature of statistical learning theory. Ahola AJ, Lassenius MI, Forsblom C, Harjutsalo V, Lehto M, Groop P-H.

Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al.

A new equation to estimate glomerular filtration rate. Ann Intern Med. Lee CH, Cook S, Lee JS, Han B. Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores. Genomics Inf. Kivimäki M, Walker KA, Pentti J, Nyberg ST, Mars N, Vahtera J, et al.

Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies. Pietzner M, Wheeler E, Carrasco-Zanini J, Kerrison ND, Oerton E, Koprulu M, et al. Synergistic insights into human health from aptamer- and antibody-based proteomic profiling.

Nat Commun. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol. Richard C, Couture P, Desroches S, Lamarche B.

Effect of the Mediterranean diet with and without weight loss on markers of inflammation in men with metabolic syndrome. Sureda A, Bibiloni MDM, Julibert A, Bouzas C, Argelich E, Llompart I, et al. Adherence to the Mediterranean Diet and Inflammatory Markers.

Ellegaard Nielsen J, Sofie Pedersen K, Vestergård K, Georgiana Maltesen R, Christiansen G, Lundbye-Christensen S, et al. Whelan CD, Mattsson N, Nagle MW, Vijayaraghavan S, Hyde C, Janelidze S, et al. Acta Neuropathol Commun.

Lindbohm JV, Mars N, Walker KA, Singh-Manoux A, Livingston G, Brunner EJ, et al. Plasma proteins, cognitive decline, and year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies. Boström G, Freyhult E, Virhammar J, Alcolea D, Tumani H, Otto M, et al.

J Alzheimers Dis. Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NC, et al. Article CAS Google Scholar. Lai KSP, Liu CS, Rau A, Lanctôt KL, Köhler CA, Pakosh M, et al. J Neurol Neurosurg Psychiatry.

Samuelsson J, Kern S, Zetterberg H, Blennow K, Rothenberg E, Wallengren O, et al. Ballarini T, Melo van Lent D, Brunner J, Schröder A, Wolfsgruber S, Altenstein S, et al. Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age.

Bayer-Carter JL, Green PS, Montine TJ, VanFossen B, Baker LD, Watson GS, et al. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment.

Arch Neurol. Thijssen EH, Verberk IM, Stoops E, Boxer AL, Teunissen CE. Delaby C, Julian A, Page G, Ragot S, Lehmann S, Paccalin M. NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline.

Chatterjee P, Zetterberg H, Goozee K, Lim CK, Jacobs KR, Ashton NJ, et al. J Neuroinflamm. Verberk IMW, Laarhuis MB, van den Bosch KA, Ebenau JL, van Leeuwenstijn M, Prins ND, et al.

Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study. Lancet Healthy Longev. Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Weiner M, et al.

Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, et al. Lancet Neurol. Benedet AL, Milà-Alomà M, Vrillon A, Ashton NJ, Pascoal TA, Lussier F, et al.

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum. JAMA Neurol. Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, et al. Transl Psychiatry. Sattlecker M, Kiddle SJ, Newhouse S, Proitsi P, Nelson S, Williams S, et al.

Müller M, Carter S, Hofer MJ, Campbell IL. Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity—a tale of conflict and conundrum. Neuropathol Appl Neurobiol. Krauthausen M, Kummer MP, Zimmermann J, Reyes-Irisarri E, Terwel D, Bulic B, et al.

J Clin Investig. Millar SR, Navarro P, Harrington JM, Shivappa N, Hébert JR, Perry IJ, et al. Dietary score associations with markers of chronic low-grade inflammation: a cross-sectional comparative analysis of a middle- to older-aged population.

Tomata Y, Shivappa N, Zhang S, Nurrika D, Tanji F, Sugawara Y, et al. Dietary Inflammatory Index and Disability-Free Survival in Community-Dwelling Older Adults. Shivappa N, Schneider A, Hébert JR, Koenig W, Peters A, Thorand B. Eur J Public Health.

Kipnis V, Subar AF, Midthune D, Freedman LS, Ballard-Barbash R, Troiano RP, et al. Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol. discussion Ho GY, Xue XN, Burk RD, Kaplan RC, Cornell E, Cushman M. Variability of serum levels of tumor necrosis factor-alpha, interleukin 6, and soluble interleukin 6 receptor over 2 years in young women.

Haslam DE, Li J, Dillon ST, Gu X, Cao Y, Zeleznik OA, et al. Stability and reproducibility of proteomic profiles in epidemiological studies: comparing the Olink and SOMAscan platforms.

Carlyle BC, Kitchen RR, Mattingly Z, Celia AM, Trombetta BA, Das S, et al. Front Neurol. Download references. Howard; Stanford Prevention Research Center, Stanford, CA Marcia L. The authors also thank the staff and participants of the ARIC study for their important contributions. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging.

The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U. Department of Health and Human Services through contracts 75ND, 75ND, 75ND, 75ND, 75ND Similar to WHI, The Atherosclerosis Risk in Communities Study ARIC is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts 75ND, 75ND, 75ND, 75ND, 75ND The ARIC Neurocognitive Study is additionally supported by U01HL, U01HL, U01HL, U01HL, and U01HL from the NIH NHLBI, NINDS, NIA, and NIDCD.

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA. Michael R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N.

Daya, Yang An, Susan M. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.

Program in Public Health, Stony Brook University School of Medicine, Stony Brook, NY, USA. BMC geriatrics ;7: Wimo A, Jonsson L, Bond J, et al. The worldwide economic impact of dementia Xu C, Sun J, Duan H, et al. Gene, environment and cognitive function: a Chinese twin ageing study.

Age and ageing ; —7. Selhub J, Bagley LC, Miller J, et al. B vitamins, homocysteine, and neurocognitive function in the elderly. The American journal of clinical nutrition ; s—s. Article CAS Google Scholar. Yaffe K, Fiocco AJ, Lindquist K, et al. Predictors of maintaining cognitive function in older adults: the Health ABC study.

Neurology ; — Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.

Archives of neurology ; —8. Psaltopoulou T, Kyrozis A, Stathopoulos P, et al. Diet, physical activity and cognitive impairment among elders: the EPIC-Greece cohort European Prospective Investigation into Cancer and Nutrition. Public health nutrition ; — Engelhart MJ, Geerlings MI, Ruitenberg A, et al.

Dietary intake of antioxidants and risk of Alzheimer disease. Jama ; —9. Roberts RO, Geda YE, Cerhan JR, et al. Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment.

Dementia and geriatric cognitive disorders ; — LaRue A, Koehler KM, Wayne SJ, et al. Nutritional status and cognitive functioning in a normally aging sample: A 6-y reassessment.

American Journal of Clinical Nutrition ; 20— Lee L, Kang SA, Lee HO, et al. Relationships between dietary intake and cognitive function level in Korean elderly people. Public Health ; —8. Nes M, Sem SW, Rousseau B, et al. Dietary intakes and nutritional status of old people with dementia living at home in Oslo.

Eur J Clin Nutr ; — CAS PubMed Google Scholar. Roberts RO, Roberts LA, Geda YE, et al. Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia. J Alzheimers Dis ; — van der Zwaluw NL, van de Rest O, Tieland M, et al. The impact of protein supplementation on cognitive performance in frail elderly.

Eur J Nutr ; — Deschamps V, Astier X, Ferry M, et al. Nutritional status of healthy elderly persons living in Dordogne, France, and relation with mortality and cognitive or functional decline.

Katsiardanis K, Diamantaras AA, Dessypris N, et al. Cognitive impairment and dietary habits among elders: the Velestino Study. J Med Food ; — Ortega RM, Requejo AM, Andres P, et al.

Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr ; —9. Velho S, Marques-Vidal P, Baptista F, et al. Dietary intake adequacy and cognitive function in free-living active elderly: a cross-sectional and short-term prospective study.

Clin Nutr ; 77— Vercambre MN, Boutron-Ruault MC, Ritchie K, et al. Long-term association of food and nutrient intakes with cognitive and functional decline: a year follow-up study of elderly French women.

British Journal of Nutrition ; — aspx Accessed 27 February htm Accessed 27 February. Nooyens AC, Bueno-de-Mesquita HB, van Boxtel MP, et al.

Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. The British journal of nutrition ; — Association AD 2 Classification and diagnosis of diabetes. Diabetes Care 38Suppl: S8—s Whelton PK, Carey RM, Aronow WS, et al.

Journal of the American College of Cardiology ; e—e Centers for Disease C, and Prevention. pdf Accessed 27 February. Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. The Journal of nutrition ; S—S; discussion S.

Bourre JM. Effects of nutrients in food on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients. CAS Google Scholar. Fernstrom JD. Large neutral amino acids: dietary effects on brain neurochemistry and function.

Amino acids ; — Young VR. Amino acids and proteins in relation to the nutrition of elderly people. Age and ageing ; S10— Requejo AM, Ortega RM, Robles F, et al.

Influence of nutrition on cognitive function in a group of elderly, independently living people. Eur J Clin Nutr ;57Suppl 1: S54—7. Petruski-Ivleva N, Kucharska-Newton A, Palta P, et al.

Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities ARIC Study. Nutrients ;9. Almeida OP, Norman P, Hankey G, et al. Successful mental health aging: results from a longitudinal study of older Australian men. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry ; 27— Kesse-Guyot E, Assmann KE, Andreeva VA, et al.

Consumption of Dairy Products and Cognitive Functioning: Findings from the SU. MAX 2 Study. J Nutr Health Aging ; — Pilleron S, Desport JC, Jesus P, et al. Diet, Alcohol Consumption and Cognitive Disorders in Central Africa: A Study from the EPIDEMCA Program.

Araki A, Yoshimura Y, Sakurai T, et al. Low intakes of carotene, vitamin B2, pantothenate and calcium predict cognitive decline among elderly patients with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int ; — Ozawa M, Ohara T, Ninomiya T, et al.

Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. J Am Geriatr Soc ; — Park KM, Fulgoni VL, 3rd. The association between dairy product consumption and cognitive function in the National Health and Nutrition Examination Survey.

Download references. We thank all individuals at the National Center for Health Statistics of the Centers for Disease Control and Prevention who were responsible for the planning and administering of NHANES and making the datasets of NHANES available on their website.

Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, Shandong, China. You can also search for this author in PubMed Google Scholar.

Objectives: The cognltive of this ontake Protein intake for cognitive function to rPotein the association of dietary Magnesium for athletic performance intake and protein sources with cognitive function ontake population aged 60 years and older. Design: Cross-sectional study. Setting: The National Health and Nutrition Examination Survey NHANES Participants: Non-institutionalized US adults aged 60 years and older. Measurements: Cognitive functions were assessed by a series of cognitive tests. Dietary protein intake was assessed by two hour dietary recall interviews. Background: To delay the onset of dementia, it is important Energizing thirst quenchers healthy adults to take Protein intake for cognitive function actions before the intke function clearly declines. Coognitive purpose of this study was to Nutrition for team sports the effect of the ingestion fynction seven selected cogitive Protein intake for cognitive function acids as a granular powder, namely, leucine, phenylalanine, and lysine supplemented with isoleucine, histidine, valine, and tryptophan on cognitive and psychosocial functions in healthy adults. Methods: A double-blind, randomized, placebo-controlled trial was conducted. A total of participants aged 55 years or older were randomly assigned to one of three groups: daily ingestion of 3 g 3gIG or 6 g 6gIG of the selected amino acids or daily ingestion of a placebo PCG. Each group ingested the test powder for 12 weeks.

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